ULAB: Computational Biology: Preprints

A preprint is a version of a scholarly article that is circulated (generally by being posted online and made freely available) without having undergone formal peer review. A preprint can be an article that is:

• posted before it is submitted for publication,
• in the process of submission to a journal for peer review and publication, or
• not intended for formal publication.

Advantages of preprints

• Rapid dissemination of research results
• Forum for null or negative results that can be difficult to publish
• Freely available preprints can be viewed by everyone with access to the internet
• There is generally no cost to authors to post
• Provide opportunities for authors to receive feedback from a wide range of readers beyond formal peer reviewers
• Published articles with preprints are cited at higher levels, increasing impact
• Can provide evidence of scientific priority

Disadvantages of preprints

• Preprints have not undergone the quality checks provided by formal peer review (although there can be extensive public comments)
• Some journals do not permit citation of preprints
• Preprints may continue to be cited after the article has been published in journal, which is the version of record
• A small number of journals may consider the posting of a preprint to be a form of prior publication, and so will not accept manuscripts that have been posted as preprints

Selected perspectives on preprints

• Watson C. Rise of the preprint: how rapid data sharing during COVID-19 has changed science forever. Nature Medicine 2022 Jan;28(1):2-5. https://doi.org/10.1038/s41591-021-01654-6. PMID: 35031791. Get it at UC
• Sarabipour S, Debat HJ, Emmott E, Burgess SJ, Schwessinger B, Hensel Z. On the value of preprints: An early career researcher perspective. PLoS Biology 2019 Feb 21;17(2):e3000151. https://doi.org/10.1371/journal.pbio.3000151. PMID: 30789895; PMCID: PMC6400415. Get it at UC
• Verma IM. Preprint servers facilitate scientific discourse. Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12630. https://doi.org/10.1073/pnas.1716857114. Epub 2017 Oct 19. PMID: 29078419; PMCID: PMC5715790. Get it at UC
• Berg JM, et al. Preprints for the life sciences. Science. 2016 May 20;352(6288):899-901. https://doi.org/10.1126/science.aaf9133. PMID: 27199406. Get it at UC

Disciplinary preprint archives

Multidisciplinary preprints